How Difficult Is Inference of Mammalian Causal Gene Regulatory Networks?
نویسندگان
چکیده
منابع مشابه
How Difficult Is Inference of Mammalian Causal Gene Regulatory Networks?
Gene regulatory networks (GRNs) play a central role in systems biology, especially in the study of mammalian organ development. One key question remains largely unanswered: Is it possible to infer mammalian causal GRNs using observable gene co-expression patterns alone? We assembled two mouse GRN datasets (embryonic tooth and heart) and matching microarray gene expression profiles to systematic...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0111661